Pharmaceutical Anastrozole/Adex 1mg x 28

Classification

Pharmaceutical Anastrozole/Adex 1mg x 28 is marketed as containing anastrozole, a non-steroidal aromatase inhibitor. It is primarily used for certain hormone receptor-positive breast cancers in postmenopausal women.

The stated 1mg x 28 refers to the advertised tablet strength and quantity.

What is Pharmaceutical Anastrozole/Adex 1mg x 28?

This product describes tablets containing 1mg of anastrozole per tablet, supplied as 28 tablets.

Anastrozole reduces the production of oestrogen by inhibiting the aromatase enzyme. Lowering oestrogen can help slow the growth of hormone-sensitive breast cancer cells.

Important product details include:

• Active ingredient and strength
• Manufacturer information
• Batch or lot number
• Expiry date
• Packaging condition
• Prescription information
• Applicable UK regulatory status

Dosage

For its licensed breast-cancer indications, the usual adult dose is 1mg once daily. Treatment duration depends on the diagnosis and treatment plan and may extend over several years.

Anastrozole should be taken exactly as prescribed. The 28-tablet pack size does not necessarily indicate the intended overall treatment duration.

How Does Pharmaceutical Anastrozole/Adex 1mg x 28 Work?

Anastrozole inhibits aromatase, the enzyme responsible for converting certain androgens into oestrogens.

In postmenopausal women, this substantially lowers circulating oestrogen levels, reducing hormonal stimulation of oestrogen-sensitive breast cancer cells.

Benefits

When appropriately prescribed, anastrozole may:

• Reduce oestrogen production
• Help treat certain hormone receptor-positive breast cancers
• Support adjuvant treatment following breast-cancer surgery
• Be used for selected advanced breast cancers
• Provide an oral aromatase-inhibitor treatment option

Some UK-authorised products also have an indication for primary prevention of breast cancer in selected postmenopausal women at moderate or high risk.

When Should You Not Take Pharmaceutical Anastrozole/Adex 1mg x 28?

Anastrozole is not intended for premenopausal women in its standard breast-cancer indications and is contraindicated during pregnancy and breastfeeding.

Particular caution is required if you have:

• Osteoporosis or low bone density
• Kidney impairment
• Liver impairment
• Cardiovascular risk factors
• A known allergy to anastrozole or its ingredients

Tamoxifen and oestrogen-containing treatments can reduce anastrozole’s pharmacological effect and should not generally be combined unless specifically directed by a specialist.

What is the Mechanism of Pharmaceutical Anastrozole/Adex 1mg x 28?

Anastrozole is a selective aromatase inhibitor. By blocking aromatase, it reduces conversion of androgens to oestrogens.

The resulting reduction in circulating oestrogen can inhibit the growth of hormone-sensitive breast cancer cells.

Uses of Pharmaceutical Anastrozole/Adex 1mg x 28

Anastrozole may be prescribed for:

• Hormone receptor-positive advanced breast cancer in postmenopausal women
• Adjuvant treatment of hormone receptor-positive early invasive breast cancer
• Continued adjuvant treatment following previous tamoxifen therapy
• Selected primary breast-cancer prevention in postmenopausal women at moderate or high risk, depending on the specific authorised product and clinical assessment

Warnings and Precautions

Important precautions include:

• Use only under appropriate medical supervision.
• Bone mineral density may need assessment because anastrozole can increase bone loss and fracture risk.
• Tell your doctor about osteoporosis or previous fractures.
• Inform your healthcare professional about liver or kidney problems.
• Tell your doctor about all medicines and supplements you take.
• Do not use additional oestrogen-containing treatments unless specifically advised.

Anastrozole can also affect cholesterol levels and may require consideration of cardiovascular risk factors.

Side Effects

Possible side effects include:

• Hot flushes
• Headache
• Nausea
• Skin rash
• Joint pain or stiffness
• Arthritis
• Fatigue or weakness
• Depression
• Bone loss/osteoporosis
• Increased cholesterol

Joint symptoms and reduced bone mineral density are particularly important considerations during longer-term treatment.

Rare but serious reactions include severe allergic reactions and serious skin reactions such as Stevens-Johnson syndrome.

Storage

Storage should follow the manufacturer’s instructions supplied with the specific product.

General considerations include:

• Keep tablets in their original packaging.
• Protect from excessive moisture and heat.
• Store according to the labelled temperature requirements.
• Keep out of the reach of children.
• Do not use after the expiry date.
• Keep the packaging securely closed.

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Frequently Asked Questions

1. What is Pharmaceutical Anastrozole/Adex 1mg x 28?

It is a product marketed as containing 1mg of anastrozole per tablet, supplied as 28 tablets. Anastrozole is an aromatase inhibitor primarily used for certain hormone-sensitive breast cancers.

2. What is anastrozole 1mg used for?

It is primarily used for hormone receptor-positive breast cancer in postmenopausal women, including selected early and advanced cancers.

3. Is 1mg a recognised anastrozole strength?

Yes. 1mg once daily is the standard adult dose for its licensed breast-cancer indications.

4. Can anastrozole affect bone health?

Yes. Lowering oestrogen can cause loss of bone mineral density and increase fracture risk, so bone health may require monitoring during treatment.

5. Is Pharmaceutical Anastrozole/Adex 1mg x 28 a UK-authorised product?

The specific product should not automatically be considered UK-authorised. Its exact formulation, manufacturer, authenticity and regulatory status should be independently verified before use.