Description
Classification
Pharmaqo Anastrozole/Adex 1mg x 50 is marketed as an oral product containing anastrozole, a selective non-steroidal aromatase inhibitor. Anastrozole reduces oestrogen production by inhibiting the aromatase enzyme. In the UK, anastrozole 1mg tablets are prescription-only medicines and are primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.
The stated 1mg x 50 indicates a labelled strength of 1mg per tablet and a quantity of 50 tablets. The specific Pharmaqo product should not automatically be regarded as a UK-authorised medicine without verification of its manufacturer, marketing authorisation and supply route.
What is Pharmaqo Anastrozole/Adex 1mg x 50?
Pharmaqo Anastrozole/Adex 1mg x 50 describes a product labelled as containing 1mg of anastrozole per tablet, supplied as 50 tablets. Anastrozole lowers circulating oestrogen by blocking the aromatase enzyme responsible for converting certain androgens into oestrogens.
For customers assessing a product, useful details include:
- Active ingredient and stated strength
- Manufacturer information
- Batch or lot number
- Expiry date
- Packaging integrity
- Marketing authorisation information
- Certificate of analysis, where available
Dosage
For UK-authorised anastrozole 1mg tablets, the recommended adult dose is one 1mg tablet once daily for the licensed indications. Treatment duration depends on the individual’s medical condition and clinical plan.
The 1mg strength should not be used to create an unsupervised dosing regimen for bodybuilding, hormone manipulation or other non-approved purposes. Anastrozole treatment should be prescribed and monitored by an appropriate healthcare professional.
How Does Pharmaqo Anastrozole/Adex 1mg x 50 Work?
Anastrozole works by inhibiting aromatase, an enzyme involved in the conversion of androstenedione and testosterone-related hormones into oestrogens. By reducing this conversion, anastrozole substantially lowers circulating oestrogen levels in postmenopausal women.
This reduction in oestrogen is particularly relevant to hormone receptor-positive breast cancer, where lowering oestrogen can reduce hormonal stimulation of cancer cells.
Benefits
The established therapeutic benefits of anastrozole relate primarily to hormone-sensitive breast cancer treatment and prevention in appropriate postmenopausal women. UK product information includes treatment of hormone receptor-positive advanced breast cancer and adjuvant treatment of hormone receptor-positive early invasive breast cancer.
Potential clinical benefits include:
- Reducing oestrogen production
- Supporting treatment of hormone receptor-positive breast cancer
- Helping reduce the risk of recurrence in appropriate patients
- Providing an alternative to certain other endocrine treatments
- Supporting primary prevention in selected higher-risk postmenopausal women
When Should You Not Take Pharmaqo Anastrozole/Adex 1mg x 50?
Anastrozole is not suitable for everyone. UK prescribing information states that it is contraindicated during pregnancy and breastfeeding and in people with known hypersensitivity to anastrozole or its excipients. It is also not recommended for children and adolescents.
Particular medical assessment is important for people with:
- Severe liver impairment
- Significant kidney impairment
- Osteoporosis or reduced bone density
- Uncertain menopausal status
- Existing cardiovascular risk factors
- Conditions requiring long-term hormone treatment
Anastrozole should not be used in premenopausal women unless specifically directed as part of specialist treatment.
What is the Mechanism of Pharmaqo Anastrozole/Adex 1mg x 50?
Anastrozole is a potent and highly selective non-steroidal aromatase inhibitor. It reduces the conversion of androgenic hormones into oestrogens by inhibiting the aromatase enzyme complex.
Lower circulating oestrogen levels can reduce stimulation of hormone receptor-positive breast cancer cells. The medicine does not have significant oestrogenic, progestogenic or androgenic activity of its own.
Uses of Pharmaqo Anastrozole/Adex 1mg x 50
Anastrozole has established UK medical uses including:
- Treatment of hormone receptor-positive advanced breast cancer
- Adjuvant treatment of hormone receptor-positive early invasive breast cancer
- Adjuvant treatment following previous tamoxifen therapy in suitable patients
- Primary prevention of breast cancer in selected postmenopausal women at moderate or high risk
Its use should be based on a confirmed diagnosis and appropriate medical assessment.
Warnings and Precautions for Pharmaqo Anastrozole/Adex 1mg x 50
Anastrozole can significantly reduce oestrogen levels, which may affect bone health, cholesterol levels and general wellbeing. The NHS notes that long-term treatment can weaken bones and increase the risk of osteoporosis, while cholesterol may also increase.
Important precautions include:
- Discuss existing bone-density problems with your prescriber.
- Follow recommended bone-density monitoring.
- Monitor cholesterol where advised.
- Report persistent or severe joint or bone symptoms.
- Tell your doctor about liver or kidney problems.
- Do not combine hormone-modifying medicines without professional advice.
Side Effects of Pharmaqo Anastrozole/Adex 1mg x 50
Common side effects associated with anastrozole can include:
- Hot flushes and sweating
- Difficulty sleeping
- Tiredness
- Low mood
- Joint or muscle discomfort
- Headache
- Nausea
- Skin changes
- Hair thinning
- Vaginal dryness
Long-term treatment can contribute to bone weakening and osteoporosis, while cholesterol levels may also increase.
Serious allergic reactions are uncommon but require urgent medical attention if symptoms such as swelling, blistering or breathing difficulties develop.
Storage for Pharmaqo Anastrozole/Adex 1mg x 50
Storage should follow the manufacturer’s instructions supplied with the specific product. UK-authorised anastrozole products may have different packaging instructions; one current UK formulation requires no special storage conditions, while its HDPE presentation should not be stored above 30°C.
General considerations include:
- Keep tablets in their original packaging.
- Protect from excessive heat and moisture.
- Keep away from direct sunlight.
- Keep out of the reach of children.
- Do not use after the stated expiry date.
- Keep the packaging securely closed.
Where to buy Pharmaqo Anastrozole/Adex 1mg x 50?
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Frequently Asked Questions
1. What is Pharmaqo Anastrozole/Adex 1mg x 50?
It is a product labelled as containing 1mg of anastrozole per tablet, supplied as 50 tablets. Anastrozole is an aromatase inhibitor that lowers oestrogen production.
2. What is anastrozole used for?
Anastrozole is primarily used for hormone receptor-positive breast cancer in postmenopausal women, including certain early and advanced forms.
3. Is 1mg a standard anastrozole strength?
Yes. UK-authorised anastrozole products are available as 1mg tablets, with the recommended adult dose generally being one 1mg tablet once daily for licensed indications.
4. What are the main risks of anastrozole?
Important concerns include bone weakening, osteoporosis, joint symptoms, hot flushes, low mood and increased cholesterol.
5. Is Pharmaqo Anastrozole/Adex 1mg x 50 a UK-authorised medicine?
The specific Pharmaqo product should not automatically be considered UK-authorised. Its manufacturer, marketing authorisation, authenticity and supply route should be independently verified before it is regarded as a legitimate UK pharmaceutical product.
