6 x ROHM Telmisartan 40mg x 50

Description

Classification

Product: 6 x ROHM Telmisartan 40mg x 50
Active ingredient: Telmisartan, as stated by the product name
Product type: Angiotensin II receptor blocker (ARB)
Form: Oral tablets
Pack size: 6 × 50 tablets
Stated strength: 40mg per tablet
Total tablets: 300

UK-authorised telmisartan 40mg tablets are prescription medicines used principally for essential hypertension and, in specified adults, cardiovascular risk reduction.

The exact formulation, excipients, manufacturer and regulatory status of the ROHM product should be confirmed from its original packaging and documentation.

What is 6 x ROHM Telmisartan 40mg x 50?

6 x ROHM Telmisartan 40mg x 50 is a bulk pack containing six packs of 50 tablets, with each tablet stated to contain 40mg of telmisartan.

Telmisartan belongs to the angiotensin II receptor blocker (ARB) class. It works by selectively blocking the AT1 receptor, preventing angiotensin II from producing several effects that contribute to increased blood pressure.

Telmisartan is available as authorised 20mg, 40mg and 80mg tablet preparations in the UK.

Dosage

For authorised telmisartan products, the usual effective dose for essential hypertension in adults is 40mg once daily. Some patients may respond to 20mg daily, while the dose may be increased to a maximum of 80mg once daily when clinically appropriate.

For cardiovascular prevention in specified patients, the recommended authorised dose is 80mg once daily. Dose selection should be made by a healthcare professional according to the patient’s condition and treatment response.

The dosing information for authorised telmisartan medicines should not automatically be applied to the ROHM product unless its formulation and regulatory status have been verified.

How Does ROHM Telmisartan Work?

Telmisartan selectively blocks the angiotensin II type 1 (AT1) receptor.

Angiotensin II normally contributes to vasoconstriction and stimulates processes that can increase blood pressure. By preventing angiotensin II from activating the AT1 receptor, telmisartan reduces these effects and promotes lower blood pressure.

The UK product information describes telmisartan as an orally active, specific and long-lasting AT1 receptor blocker.

Potential Benefits

When appropriately prescribed, telmisartan may provide several clinically relevant benefits, including:

• Reduction of elevated blood pressure
• Lowering of cardiovascular risk in certain eligible patients
• Reduction of angiotensin-II-mediated vasoconstriction
• Support for long-term blood-pressure control

Authorised UK telmisartan 40mg tablets are indicated for treatment of essential hypertension in adults. They are also indicated for cardiovascular risk reduction in adults with specified atherothrombotic cardiovascular disease or type 2 diabetes with documented target-organ damage.

When Should You Not Take ROHM Telmisartan?

Telmisartan should not be used in people with a known hypersensitivity to telmisartan or any relevant formulation ingredients.

UK product information also identifies the following contraindications:

• Second or third trimester of pregnancy
• Biliary obstructive disorders
• Severe hepatic impairment
• Certain combinations involving aliskiren in patients with diabetes or renal impairment

Women who are pregnant or planning pregnancy should discuss treatment with a healthcare professional, as medicines acting on the renin-angiotensin system can cause serious fetal harm later in pregnancy.

Mechanism

Telmisartan selectively binds to the AT1 receptor, displacing angiotensin II from its binding site.

Blocking AT1 receptors prevents the principal cardiovascular effects associated with angiotensin II, including vasoconstriction. Telmisartan also reduces plasma aldosterone concentrations.

Unlike ACE inhibitors, telmisartan does not inhibit angiotensin-converting enzyme or prevent the breakdown of bradykinin.

Uses

Authorised telmisartan medicines are used primarily for:

• Essential hypertension in adults
• Cardiovascular prevention in specified adults with established atherothrombotic cardiovascular disease or type 2 diabetes with documented target-organ damage

The exact licensed indications of the ROHM product should be verified independently before describing it as a UK-authorised medicine.

Warnings and Precautions

Medical supervision is particularly important for people with:

• Kidney impairment
• Liver impairment
• Low blood volume or dehydration
• Low blood pressure
• Cardiovascular disease
• Diabetes
• Conditions affecting potassium levels

Telmisartan can affect renal function and potassium concentrations. Patients at risk may require monitoring of kidney function and electrolytes.

In severe renal impairment or haemodialysis, UK product information recommends a lower starting dose of 20mg. In mild-to-moderate hepatic impairment, the dose should not exceed 40mg once daily, while severe hepatic impairment is a contraindication.

Telmisartan should also not be combined with aliskiren in patients with diabetes or significant renal impairment because of the associated contraindication.

Side Effects

Possible adverse effects associated with telmisartan include:

• Dizziness
• Headache
• Low blood pressure
• Diarrhoea
• Increased potassium levels
• Changes in kidney function
• Muscle pain
• Back pain
• Fatigue

Less common or clinically significant reactions can include fainting, renal impairment and angioedema.

Seek urgent medical attention for swelling of the face, lips, tongue or throat, particularly if accompanied by difficulty breathing or swallowing.

Storage

Store telmisartan according to the manufacturer’s instructions.

Authorised 40mg telmisartan tablets should generally be kept in their original packaging and protected from moisture. Some formulations are hygroscopic and should remain sealed in their blister until shortly before administration.

Keep medicines out of the reach and sight of children and do not use them beyond the stated expiry date.

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Frequently Asked Questions

1. What is 6 x ROHM Telmisartan 40mg x 50?

It is a bulk pack containing six packs of 50 tablets, with each tablet stated to contain 40mg of telmisartan, giving 300 tablets in total.

2. What is telmisartan used for?

Authorised telmisartan medicines are primarily used to treat essential hypertension in adults. Certain authorised formulations are also used to reduce cardiovascular morbidity in specified high-risk adults.

3. How does telmisartan lower blood pressure?

Telmisartan blocks angiotensin II from activating AT1 receptors. This reduces angiotensin-II-mediated vasoconstriction and other blood-pressure-raising effects.

4. Can telmisartan affect the kidneys or potassium levels?

Yes. Telmisartan can affect renal function and potassium concentrations, particularly in people with kidney disease or those taking other medicines that affect potassium. Appropriate monitoring may therefore be required.

5. Is ROHM Telmisartan 40mg authorised in the UK?

The exact UK regulatory status of this ROHM product should be independently verified. Authorised 40mg telmisartan medicines are listed in the UK medicines compendium, but that does not establish that the specific ROHM product is UK-authorised.